Darmstadt is a city in the state of Hesse in Germany, located in the southern part of the Rhine-Main-Area. Darmstadt has a population around 150,000 . Darmstadt holds the official title "City of Science" as it is a major centre of scientific institutions, universities, and high-technology companies. The European Space Operations Centre is located in Darmstadt, as well as GSI Centre for Heavy Ion Research, where several chemical elements such as bohrium, meitnerium, hassium, darmstadtium, roentgenium, and copernicium were discovered. The existence of the following elements were also confirmed at GSI Centre for Heavy Ion Research: nihonium, flerovium, moscovium, livermorium, and tennessine. Darmstadt is also the seat of the worlds oldest pharmaceutical company, Merck, which is the citys largest employer. Darmstadt was formerly the capital of a sovereign country, the Grand Duchy of Hesse and its successor, the Peoples State of Hesse, a federal state of Germany. As the capital of an increasingly prosperous duchy, the city gained some international prominence and remains one of the wealthiest cities in Europe. In the 20th century, industry, as well as large science and electronics sectors became increasingly important, and are still a major part of the citys economy. It is also home to the football club SV Darmstadt 98. Darmstadt, Indiana was named after Darmstadt and for the former Royal Family.